Yes, TotalBoat Wet Edge Topside Paint can be applied over TotalBoat Wood Sealer Varnish Primer. Once the Wood Sealer has fully cured, sand with 320-grit sandpaper. Dampen a clean cotton rag with TotalBoat Brushing Thinner 100 or TotalBoat Spray Thinner 101 to remove the sanding residue before applying Wet Edge.